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KMID : 0617320010100010140
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Journal of Pharmacetical Sceiences Ewha Womans University
2001 Volume.10 No. 1 p.140 ~ p.148
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Moled porous poly (L-lactide) membranes for guided bone regeneration with enhanced effects by controlled growth factor release
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Lee, Seung Jin
Park, Yoon Jeong/Park, Si Nae/Lee, Yong Moo/Seol, Yang Jo/Ku, Young/Chung, Chong Pyoung
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Abstract
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The aim of this study was to develop plateletderived growth factor(PDGG-BB) loaded moldable porous poly(l-Lactide)(PLlA)-tricalcium phosphate(TCP) membranes for guided bone regeneration (GBR) theraphy. the membranes were designed to fit various types oof bone defect sites. PDGF-BB-dissolved PLLA-TCP in methylene chloride-ethyl acetate solution was cast on a dome shaped metallic mold to fabricate a model membrane. The release rate of PDGF-BB, the osteoblast attachment test, and guided bone regeneration potential were evaluated with PDGF-BB-loaded PLLA-TCP membranes. Regular pores were generated throughout the membrane mainly due to phase inversion of PLLA-methylene chloride-ethyl acetate solution. A therapeutic amount of PDGE-BB was released from the membrane. The release rate could be controlled by varying the initial loading content of PDGF-BB. A significant amount of cells attached onto the PDGF-BB-loaded membrane rather than onto the unloaded membrane. Dome shaped bone formation was achieved in rabbit calvaria at 4 weeks. This indicated that restoration of bone defects to the bone´s original shape can be made possibly by using molded membranes, which guide bone regeneration along with providing sufficient spaces. Bone forming efficiency was increased remarkably due to PDGF-BB release from PLLA-TCP membranes. These results suggested that the PDGF-BB releasing molded PLLA-TCP membrane may potentially improve GBR efficiency in various types of bone defects.
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